Treatment News : FDA Releases Updated Drug Interaction Information for Kaletra

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February 4, 2013

FDA Releases Updated Drug Interaction Information for Kaletra

The U.S. Food and Drug Administration (FDA) has approved revisions to the label of the antiretroviral (ARV) Kaletra (lopinavir/ritonavir) in order to include new information on drug interactions. These include:

  • Anticoagulants: Xarelto (rivaroxaban). Kaletra raises Xarelto levels and can raise the risk of increased bleeding. Avoid combining the two drugs.
  • Anticonvulsants: Lamictal (lamotrigine) and valproate. Kaletra can lower their levels, potentially requiring a higher dose.
  • Corticosteroids (systemic): Uceris (Budesonide) and prednisone. Combining Kaletra with either drug can increase steroid concentrations and reduce cortisol concentrations in the blood.
  • Hepatitis C protease inhibitors: Victrelis (boceprevir) and Incivek (telaprevir). Use in combination with Kaletra is not recommended.
  • Inhaled or intranasal steroids: Uceris and similar brands. Use in combination is not recommended unless the potential benefit outweighs the risk of increased steroid concentrations and reduced serum cortisol concentrations.
  • PDE5 inhibitors: Stendra (avanafil). Do not combine the drugs, because a safe and effective dose of avanafil has not yet been established.
  • Studies show no clinically significant interaction between Kaletra and Isentress (raltegravir).
To see the FDA release, click here.

Search: U.S. Food and Drug Administration, FDA, HIV, Kaletra, drug interaction, lopinavir/ritonavir, Xarelto, rivaroxaban, Lamictal, lamotrigine, Uceris, Budesonide, Victrelis, boceprevir, Incivek, telaprevir, Stendra, avanafil, Isentress, raltegravir.


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