Treatment News : 'Intensified' Antiretroviral Regimen Reduces Viral Shedding in Semen

POZ - Health, Life and HIV
Subscribe to:
POZ magazine
Join POZ: Facebook MySpace Twitter Pinterest
Tumblr Google+ Flickr MySpace
POZ Personals
Sign In / Join

Back to home » Treatment News » February 2013

Most Popular Links
Most Popular Lessons

The HIV Life Cycle


Herpes Simplex Virus

Syphilis & Neurosyphilis

Treatments for Opportunistic Infections (OIs)

What is AIDS & HIV?

Hepatitis & HIV

20 Years Ago In POZ

More Treatment News

Click here for more news

Have news about HIV? Send press releases, news tips and other announcements to


February 27, 2013

'Intensified' Antiretroviral Regimen Reduces Viral Shedding in Semen

The addition of Selzentry (maraviroc) and Isentress (raltegravir) to a standard triple drug antiretroviral cocktail rapidly suppresses HIV viral load in semen and significantly reduces the likelihood of intermittent, low level shedding of the virus in seminal fluid, aidsmap reports. Researchers published their findings in the online edition of The Journal of Infectious Diseases of this study of 13 gay men who began this intensified therapy and 25 controls who took a standard triple-drug regimen of antiretrovirals (ARVs). None of the participants had a sexually transmitted infection (STI), which has been shown to cause viral shedding in semen.

After recent studies have shown that suppressing viral load drastically reduces the likelihood of transmissions, other research has identified individuals who maintain an undetectable viral load in their blood, but who still experience isolated HIV shedding (IHS) in their semen, raising the possibility that they still may be intermittently infectious.  There have indeed been isolated reports of such transmissions.

Those taking the intensive therapy experienced more rapid viral suppression in their semen. IHS was found in more than one clinic visit in two participants (15 percent) on intensive therapy compared with 12 of the controls (48 percent).

After one of the participants maintained an undetectable viral load in his blood but a detectable seminal viral load for 14 months after beginning intensified treatment, the investigators observed another cohort to find if there was viral shedding in men taking long-term therapy. They examined blood and semen samples from 26 men who had been on long-term standard ARVs, all of whom had no STIs and an undetectable viral load in the blood.  

Among those in this group taking ARVs for less than six months, about half had intermittently detectable virus in their semen. Meanwhile, only 20 percent of those taking therapy for one to three years had detectable seminal virus; and none of those on treatment for more than three years did.

To read the aidsmap story, click here

To read the study abstract, click here

Search: Intensified antiretroviral regimen, ARV, Selzentry, maraviroc, Isentress, raltegravir, Journal of Infectious Diseases, sexually transmitted infection, STI, isolated HIV shedding, IHS, undetectable viral load.

Scroll down to comment on this story.


(will display; 2-50 characters)


(will NOT display)


(will display; optional)

Comment (500 characters left):

(Note: The POZ team reviews all comments before they are posted. Please do not include either ":" or "@" in your comment. The opinions expressed by people providing comments are theirs alone. They do not necessarily reflect the opinions of Smart + Strong, which is not responsible for the accuracy of any of the information supplied by people providing comments.)

Comments require captcha.
Please enter this number for verification:

| Posting Rules

Show comments (2 total)

[Go to top]

Facebook Twitter Google+ MySpace YouTube Tumblr Flickr Instagram
Quick Links
Current Issue

HIV Testing
Safer Sex
Find a Date
Newly Diagnosed
HIV 101
Disclosing Your Status
Starting Treatment
Help Paying for Meds
Search for the Cure
POZ Stories
POZ Opinion
POZ Exclusives
Read the Blogs
Visit the Forums
Job Listings
Events Calendar
POZ on Twitter

Ask POZ Pharmacist

Talk to Us
Did you participate in an event for National Black HIV/AIDS Awareness Day 2016?


more surveys
Contact Us
We welcome your comments!
[ about Smart + Strong | about POZ | POZ advisory board | partner links | advertising policy | advertise/contact us | site map]
© 2016 Smart + Strong. All Rights Reserved. Terms of use and Your privacy.
Smart + Strong® is a registered trademark of CDM Publishing, LLC.